Rac-Dependent Monocyte Chemoattractant Protein-1 Production Is Induced by Nutrient Deprivation

Rac-dependent monocyte chemoattractant protein-1 production is induced by nutrient deprivation.

Under ischemic conditions, the vessel wall recruits inflammatory cells. Human aortic endothelial cells (HAECs) exposed to hypoxia followed by reoxygenation produce monocyte chemoattractant protein-1 (MCP-1); however, most experiments have been performed in the presence of nutrient deprivation (ND). We hypothesized that ND rather than hypoxia mediates endothelial MCP-1 production during ischemia...

Chemoattractant Protein-1 Production by Hypoxia Selectively Inhibits Monocyte

Macrophages Chemoattractant Protein-1 Production by Hypoxia Selectively Inhibits Monocyte

Monocyte Chemoattractant Protein-1 Synthesis

Production of monocyte chemoattractant protein 1 in tuberculosis patients.

To investigate the role of monocyte chemoattractant protein 1 (MCP-1) in the immune response to Mycobacterium tuberculosis, we studied MCP-1 production in tuberculosis patients. CD14+ blood monocytes from tuberculosis patients spontaneously expressed higher levels of MCP-1 mRNA and protein than CD14+ monocytes from healthy tuberculin reactors. MCP-1 production in lymph nodes from tuberculosis p...